92
35
th IEEE PHOTOVOLTAIC SPECIALISTS CONFERENCE
TORONTO • CANADA
SIEMENS
Platelet Morphology and Coagulation
Activation Markers: Diagnostic Utility in
Hemostatic Disorders
Saturday, May 11, 2013 | 12:00PM - 1:45PM
Dominion South
Chairman:
Dr. Steve Kitchen , Clinical Scientist, Department of
Coagulation, Royal Hallamshire Hospital , Sheffield, UK
Clinical and laboratory approach to disseminated
intravascular coagulopathy in different clinical scenarios
and the role of D-dimer
Professor Alhossain A. Khalafallah
Consultant Hematologist, School of Human Life Sciences
The Launceston General Hospital, Tasmania
Program Overview:
Disseminated intravascular coagulation (DIC) is a serious
complication of many clinical scenarios including infection/
sepsis, malignancy, and trauma or surgery. DIC remains a
clinical diagnosis supported by laboratory data.
In the diagnosis of DIC, there are several key contributing
factors, including:
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DIC scoring system introduced by the ISTH/SSC, including platelet
count, PT, fibrinogen and D-dimer levels
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The role of D-dimer as the key marker for diagnosis and prognosis
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Diagnostics criteria, D-dimer sensitivity, and negative predictive value
In addition, the speaker will share relevant experience with the
INNOVANCE® D-Dimer assay in a single center prospective study.
Platelet parameters and morphology investigation: where
these can help in diagnosing platelet disorders
Dr. Veronique Latger- Cannard
Medical Biologist, Biological Hematology Service
University Hospital of Nancy, Vandoeuvre-Les-Nancy, France
North-East Competence Center of Platelet Disorders, France
Program Overview:
Inherited thrombocytopenias (IT) are heterogeneous disorders
affecting platelet count and function. Distinguishing IT from
immune thrombocytopenia (ITP) is a practical challenge,
and therefore, patients are at risk of misdiagnosis and
inappropriate treatment such as administration of intravenous
steroids, immunoglobulins and/or needless splenectomy.
Diagnostic difficulties reported in literature will be illustrated
by clinical cases from the speaker’s individual experience.
Areas of interest in the diagnosis of IT include:
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Platelet size and morphology analysis.
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MPV values—differences between hematology analyzers
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The role of MPV, PCT, PDW, MPC, PCDW, MPM, and PMDW
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Specific platelet phenotype and algorithms based on the platelet
parameter assessment
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